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KMID : 0900920000240020189
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Korean journal of Animal Reproduction
2000 Volume.24 No. 2 p.189 ~ p.197
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Studies on the Effects of Antler Extract in Osteoporosis-Induced Rats II. Effect of Antler Extract on Body Weight It, Femur Weight It, Bone Ash Quantity, Organ Weight and Histological in Osteoporosis-Induced Rats
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Kim S.-K.
Kim S.-W.
Kim M.-S.
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Abstract
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In this study, we investigated the preventive and therapeutic effects of antler-extract for osteoporosis. Rats were ovariectomized bilaterally and were fed up with Ca- and P-free diet in order to induce osteoporosis. Body weight, organ weight, the weight of femur and bone ash quantity were examined for 5 weeks. We also performed histological and electronical microscopic examinations. 1. After adminstration of female and male antler extract to osteoporosis-induced rats at the doses of 625 and 1250 mg/kg, respectively, the body weights were significantly increased compared with those of normal control group′s which was 230.2:t2.3-281.0:t2.5g (p＜0.05). 2. The weights of both right and left femur of osteoporosis-induced rats, administered with female or male antler-extract, little decreased compared with those of normal control group. 3. The bone ash quanties of femur of osteoporosis-induced rats, administered with female or male antler-extract, little decreased compared with those of normal control group. 4. The weights of liver, spleen, and kidney of osteoporosis-induced rats, administered with female or male antler-extract, decreased compared with those of normal control group. 5. Histological and electronic microscopical findings were (1) that in normal control rats the connectional of lacunae appeared well and were without loss of bone mineral, (2) that in ovariectomized rats the connections of lacunae were mostly broken and were with loss of bone mineral compared with those of normal control rats, (3) that in osteoporosis-induced rats, administrated with female or male antler-extract, the shape of lacunae and the connections of them were similar to those of normal control rats. These findings suggest a possible protective and therapeutic effects of female or male antler extract against bone loss in ovariectomized rats.
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KEYWORD
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Osteoporosis, Estradiol, Calcitonin, Osteocalcin, Ca, P, ALP
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